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Mechanism of Diverticulosis Development
Diverticula typically develop when increased pressure within the colon causes the mucosal and submucosal layers to protrude through weak spots in the muscular layer. This process is influenced by factors such as:
- A diet low in fiber
- Obesity
- Physical inactivity
- Smoking
- Regular use of certain medications
- Alterations in gastrointestinal microflora
Chronic inflammation leading to muscle layer hypertrophy



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